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Cure2Children at Duke University

This August Duke University held a workshop with comprehensive educational sessions on the process of Evidence-Based Practice in Pediatric Oncology Nursing. The workshop was supported by the Alex’s Lemonade Stand Foundation for Childhood Cancer.
Many expert pediatric oncology nurses from around the US were in attendance to present their projects on evidence-based practices. Cure2Children Foundation’s project was selected by the Evidence-based/Research Committee of Association of Paediatric Haematology Oncology Nursing (APHON) and Duke University for presentation at the workshop. Sulman Siddique, International nursing coordinator of the Cure2Children Foundation, was given the opportunity to present the findings of the project.
This project is focused on finding the best evidence to reduce febrile non-heamolytic transfusion reaction (FNHTR) in children, particularly in children with hemoglobinopathies (blood disorders) who require regular blood product transfusions. Project is relevant in all pediatric haematology oncology settings. The findings of the project will dictate the best practice in blood transfusion therapy worldwide and will also be used to make recommendations for global practice change. Project findings will be published most likely in the December 2013 issue of the Journal of Paediatric Oncology Nursing (JOPON).
Sulman was awarded a certificate in appreciation of his work as a Pediatric Oncology Nursing Evidence-Based Practice team leader by Dr. Marilyn Hockenberry, Professor of Nursing and Evidence-Based Practice at Duke University.
Some facts about the significance of transfusion reactions:
Transfusion related adverse reactions are one of the leading causes of mortality both in the US (FDA, 2007) and in low income countries (De Graff et al, 2009).
Febrile non-haemolytic transfusion reactions (FNHTRs) where antibodies act against donor leukocytes and allergic reactions, both considered immunological adverse events are the most common transfusion reactions (Geiger 2007).
Febrile transfusion reactions are typically defined as a one-degree centigrade increase in temperature from the baseline during or within three hours of transfusion, which cannot be explained by sepsis or a haemolytic reaction.
Little is known about the exact risk for developing FNHTRs or allergic reactions after transfusion, and the optimal management approach to FNHTR’s is controversial. Therefore, more research is needed to come to an evidence based conclusion on the optimal management of FNHTR’s.


Posted by: Cure2Children